Author

Hexin Chen

University of South CarolinaORCID 0000-0001-9300-0859Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Gourab Gupta· 3 shared Conor PulliamiD· 2 shared Dan XueiD· 2 shared Daping FaniD· 2 shared Jie LiiD· 2 shared Manikanda Raja Keerthi RajaiD· 2 shared Mingming XuiD· 2 shared Zhuo ShangiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

Gourab Gupta

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 11, 2026

Genome Mining of the Tumor Microbiome Reveals Biosynthetic Diversity and Potential Tumor-modulating Metabolites

Conor Pulliam, Mingming Xu, Katherine S. Holandez-Lopez…·Jie Li

The paper surveys the biosynthetic potential of the human tumor microbiome, identifying novel metabolites and their potential roles in tumor pathology.

DOI 10.64898/2026.08.08.743306

humanmetagenomics

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Cancer Biologynpj Breast CancerPeer-reviewedJan 17, 2026

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson…·Hexin Chen

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

6 citationstop 2%

mousebulk RNA-seq

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BiochemistryJournal of the American Chemical SocietyPeer-reviewedDec 28, 2024

Discovery of A Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads

Dan Xue, Mingming Xu, Michael D. Madden…·Jie Li

This paper discovers a new class of cancer immunogenic chemotherapeutic leads called aspercyclicins through a high-throughput screening platform and structural elucidation techniques.

17 citationstop 4%

metabolomicsexperimental assay

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