Loss of the Wnt/β-catenin pathway in microglia of the developing brain drives pro-inflammatory activation leading to white matter injury
Juliette Van Steenwinckel, Anne-Laure Schang, Michelle L Krishnan, Vincent Degos, Andrée Delahaye-Duriez, Cindy Bokobza, Franck Verdonk, Amélie Montané, Stéphanie Sigaut, Olivier Hennebert, Sophie Lebon, Leslie Schwendimann, Tifenn Le Charpentier, Rahma Hassan-Abdi, Gareth Ball, , Pierre Gressens
The paper shows that reduced Wnt/β-catenin signaling in microglia of the developing brain causes pro-inflammatory activation and white matter injury, and that restoring this pathway can prevent these effects.
bioRxiv · May 31, 2018 · PreprintImmunology