Pengcheng Zhou

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes

The paper shows that late-entering B cells in germinal centers mainly become memory B cells that recognize less common antigen parts.

Therapeutic interleukin-2 rewires skeletal-immune circuits to reverse postmenopausal bone loss

This study shows that low-dose IL-2 therapy reverses postmenopausal bone loss by modulating immune cells and osteoclast activity in mice.

Affinity maturation of antibody responses is mediated by differential plasma cell proliferation

The paper shows that high-affinity B cells divide more and receive more Tfh help, leading to affinity maturation in plasma cells.

IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

This study shows IL-2 enhances CD8+ T cell effector function but inhibits CXCR5+ TPEX cell formation and follicular infection control in chronic LCMV infection.