This study identifies SAM68 as a regulator of cardiomyocyte differentiation by enhancing Gata4 translation through RNA-binding in mouse embryonic stem cells.

bioRxiv · Jan 11, 2022 · PreprintMolecular Biology

Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1

Rosario Avolio, Marta Inglés‐Ferrándiz, Annagiulia Ciocia, Olga Coll, Sarah Bonnin, Tanit Guitart, Anna Ribó Rubio, Fátima Gebauer

This study identifies CSDE1 as a tumor suppressor that coordinates post-transcriptional mechanisms to enforce oncogene-induced senescence in mouse keratinocytes.

Cell Reports · Jan 1, 2022Peer-reviewedMolecular Biology

Environmental enrichment induces epigenomic and genome organization changes relevant for cognitive function

Sergio Espeso‐Gil, Aliaksei Z. Holik, Sarah Bonnin, Shalu Jhanwar, Sandhya Chandrasekaran, Roger Piqué-Regi, Júlia Albaigès, Michael Maher, Jon Permanyer, Manuel Irimia, Marc R. Friedländer, Meritxell Pons‐Espinal, Schahram Akbarian, Mara Dierssen, Philipp G. Maass, , Stephan Ossowski

This study shows environmental enrichment alters chromatin structure, transcription factor binding, and 3D genome organization in mice, affecting cognitive function and gene regulation.

Frontiers in Molecular Neuroscience · May 5, 2021Peer-reviewedNeuroscience