Selahattin Can Özcan

GLproxScape reconstructs spatial chromatin occupancy landscapes from genomic locus proteomics data by modeling per-region enrichments as spatial measurements.

This study identifies metabolic and signaling pathways that enable pancreatic cancer cells with centrosome amplification to survive stress, highlighting vulnerabilities for therapeutic targeting.

The paper uses proximity labeling and mass spectrometry to map NEK2 interactions across the cell cycle, revealing a NEK2-NUSAP1 degradation pathway.

This paper screens epigenetic drugs to identify Type I PRMT inhibitors that inhibit lysosomal exocytosis and enhance chemotherapy efficacy in cancer.