Author

Ceyda Açılan

Koç UniversityORCID 0000-0002-8936-3267Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Selahattin Can ÖzcaniD· 3 shared Adam P. CribbsiD· 2 shared Batuhan Mert KalkaniD· 2 shared Beste KanevetciiD· 2 shared Buse CevatemreiD· 2 shared Enes CicekiD· 2 shared Martin PhilpottiD· 2 shared Nareg Pinarbasi DegirmenciiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

Selahattin Can ÖzcanORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

GLproxScape reconstructs spatial chromatin occupancy landscapes from tiled genomic locus proteomics

Selahattin Can Özcan, Baris Sergi, Büşra Yildirim, Umut Cagiral, Mehmet Gönen, Ceyda Açılan

GLproxScape reconstructs spatial chromatin occupancy landscapes from genomic locus proteomics data by modeling per-region enrichments as spatial measurements.

bioRxiv · Jul 3, 2026 · PreprintBioinformatics

Chemical screens identify HDAC6 as an epigenetic vulnerability in acquired Temozolomide-resistant models of glioblastoma

Feridun Aksu, Buse Cevatemre, Nareg Pinarbasi Degirmenci, Ezgi Yağmur Kala, Duygu Uçku, Martin Philpott, Adam P. Cribbs, James E. Dunford, Udo C. T. Oppermann, Ceyda Açılan, Tugba Bagci Onder

The paper identifies HDAC6 as an epigenetic vulnerability in TMZ-resistant glioblastoma models and shows HDAC6 inhibitors can restore TMZ sensitivity.

bioRxiv · May 11, 2026 · PreprintCancer Biology

Stress adaptation pathways and HA-CD44 signaling maintain the survival of pancreatic cancer cells with centrosome amplification

Selahattin Can Özcan, Evrim Goksel, Batuhan Mert Kalkan, Enes Cicek, Beste Kanevetci, Ceyda Açılan

This study identifies metabolic and signaling pathways that enable pancreatic cancer cells with centrosome amplification to survive stress, highlighting vulnerabilities for therapeutic targeting.

Cell Communication and Signaling · Apr 7, 2026Peer-reviewedCancer Biology

Proximity labeling reveals cell cycle-specific NEK2 interactions and a regulatory axis controlling NUSAP1 stability

Enes Cicek, Selahattin Can Özcan, Beste Kanevetci, Batuhan Mert Kalkan, Nazlı Ezgi Özkan, Nurhan Özlü, Ceyda Açılan

The paper uses proximity labeling and mass spectrometry to map NEK2 interactions across the cell cycle, revealing a NEK2-NUSAP1 degradation pathway.

bioRxiv · Jan 27, 2026 · PreprintCancer Biology

Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer

Ozlem Yedier-Bayram, Ahmet Cingöz, Ebru Yilmaz, Ali Cenk Aksu, Beril Esin, Nareg Pinarbasi Degirmenci, Ayşe Derya Cavga, Beyza Dedeoğlu, Buse Cevatemre, Hamzah Syed, Martin Philpott, Adam P. Cribbs, Udo C. T. Oppermann, Nathan A. Lack, Ceyda Açılan, , Tugba Bagci Onder

The paper identifies BRPF1 as a key regulator of Taxol resistance in TNBC through genetic and chemical screens, showing its inhibition sensitizes resistant cells to chemotherapy.

Experimental & Molecular Medicine · Jun 29, 2025Peer-reviewedCancer Biology