Batuhan Mert Kalkan

This study identifies metabolic and signaling pathways that enable pancreatic cancer cells with centrosome amplification to survive stress, highlighting vulnerabilities for therapeutic targeting.

The paper uses proximity labeling and mass spectrometry to map NEK2 interactions across the cell cycle, revealing a NEK2-NUSAP1 degradation pathway.

The paper develops small molecule inhibitors of MEIS1 that modulate HSC activity and show efficacy in vitro and in vivo.

This study develops CRISPR/Cas9 strategies to correct HBB gene mutations in human cells using HDR, showing longer gRNAs have higher target affinity.