Leonardo Pardo

This study determines the cryo-EM structures of KSHV-GPCR in complex with Gi and CXCL1, revealing structural mechanisms of constitutive activation and ligand binding.

The paper shows a bivalent ligand enhances CB2R homodimerization, leading to increased Gi binding potency and β-arrestin recruitment.

The paper analyzes natural variants in human olfactory receptors to reveal diversity and functional implications of mutations across populations.