Claudia Llinás del Torrent

Programming Targeted Immune Cell Migration Using Orthogonal Chemokine-Receptor Pairs

This study engineers orthogonal chemokine-receptor pairs to enable targeted immune cell migration and collective swarming behavior in engineered T cells.

Allosteric Gating Mechanism Regulates Odorant Selectivity and Antagonism in Odorant Receptors

This study investigates how odorant receptors regulate selectivity and antagonism through allosteric gating mechanisms using simulations and experiments.

Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling

The paper shows a bivalent ligand enhances CB2R homodimerization, leading to increased Gi binding potency and β-arrestin recruitment.

Engineered odorant receptors illuminate structural principles of odor discrimination

The paper uses engineered odorant receptors to uncover structural principles of odor discrimination by solving cryoEM structures of consensus ORs and comparing their ligand recognition properties.