Author

Gizem Inak

Max Delbrück Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandro PrigioneiD· 3 shared Agnieszka Rybak‐WolfiD· 2 shared Annika ZinkiD· 2 shared Barbara MlodyiD· 2 shared Ertan MayatepekiD· 2 shared Markus SchuelkeiD· 2 shared Nikolaus RajewskyiD· 2 shared Paweł LisowskiiD· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Alessandro PrigioneORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Expanding GABAergic Neuronal Diversity in PSC-Derived Disease Models

Ruiqi Hu, Linda L. Boshans, Yiran Tao, Bohan Zhu, Junglong Li, Xindi Li, Rui Dang, Marianna Liang, Peiwen Cai, Mark M. Youssef, Gizem Inak, Yingnan Song, Xuran Wang, Alexander M. Tsankov, Joseph D. Buxbaum, , Nan Yang

This study develops a method to generate diverse GABAergic neurons from PSCs using TFs and signaling inhibition, showing distinct subtype compositions and disease relevance.

bioRxiv · Dec 3, 2024 · PreprintDevelopmental Biology

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease

Carmen Menacho, Satoshi Okawa, Iris Álvarez‐Merz, Annika Wittich, Mikel Muñoz‐Oreja, Paweł Lisowski, Tancredi Massimo Pentimalli, Agnieszka Rybak‐Wolf, Gizem Inak, Shiri Zakin, Mathuravani A. Thevandavakkam, Laura Petersilie, Andrea Zaliani, Barbara Mlody, Annette Seibt, , Alessandro Prigione

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

bioRxiv · Jul 8, 2024 · PreprintNeuroscience

PiggyBac Transposable Element-derived 1 controls Neuronal Progenitor Identity, Stress Sensing and mammal-specific paraspeckles

Tamás Raskó, Amit Pande, Kathrin Radscheit, Annika Zink, Manvendra Kumar Singh, Christian Sommer, Gerda Wachtl, Orsolya Kolacsek, Gizem Inak, Attila Szvetnik, Spyros Petrakis, Mario Bunse, Vikas Bansal, Matthias Selbach, Tamás István Orbán, , Zsuzsanna Izsvák

The paper investigates PGBD1's role in neuronal progenitor identity, stress sensing, and mammal-specific paraspeckles, showing its dual function in DNA binding and protein interaction.

bioRxiv · May 19, 2021 · PreprintMolecular Biology

SURF1 mutations causative of Leigh syndrome impair human neurogenesis

Gizem Inak, Agnieszka Rybak‐Wolf, Paweł Lisowski, Tancredi Massimo Pentimalli, René Jüttner, Petar Glažar, Karan Uppal, Emanuela Bottani, Dario Brunetti, Christopher Secker, Annika Zink, David Meierhofer, Marie‐Thérèse Henke, Monishita Dey, Ummi Ciptasari, , Alessandro Prigione

This study shows SURF1 mutations impair human neurogenesis by generating patient-derived iPS cells and demonstrating defects in neuronal differentiation and bioenergetics.

Nature Communications · Mar 26, 2021Peer-reviewedNeuroscience