Agnieszka Rybak‐Wolf

Tau spreading coordinates intercellular lipid flux enhancing neuronal resilience to lipid toxicity

This study shows that spreading tau coordinates lipid homeostasis by promoting neuronal lipid efflux and enhancing resilience to lipid toxicity.

MicroRNAs are required within a critical time window to define neural patterning during early human brain development

The paper shows miRNAs are essential during a specific time window for proper neural patterning in human brain development, with disruption causing defects in forebrain identity.

Staufen2 modulates the temporal dynamics of human neurogenesis in vitro

This study shows that STAU2 regulates human neurogenesis by affecting transcription factors, miRNA control, and progenitor maintenance, leading to changes in neural differentiation and organoid development.

UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis

The paper shows UBE3C regulates cortical neurogenesis and glial fate through m6A methylation, with mutations disrupting this process and offering therapeutic targets.

Transcriptome-wide analysis of circRNA and RBP profiles and their molecular and clinical relevance for GBM

The paper analyzes circRNA and RBP expression in GBM to identify their interactions and clinical relevance as stratification markers.

Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease

This study identifies Arl8b as a potential biomarker for Alzheimer's disease by analyzing proteomic changes in 5xFAD mouse brain regions and CSF from AD patients.

SURF1 mutations causative of Leigh syndrome impair human neurogenesis

This study shows SURF1 mutations impair human neurogenesis by generating patient-derived iPS cells and demonstrating defects in neuronal differentiation and bioenergetics.

Neurodegeneration in human brain organoids infected with herpes simplex virus type 1

This study infects human brain organoids with HSV-1 and identifies molecular and cellular changes associated with neurodegeneration.