The paper determines the structure of C9orf72 RAN translation initiation complexes and identifies a key RNA-RNA interaction that drives DPR production, suggesting a therapeutic target.

DOI 10.64898/2026.10.25.761709

humanmultiome

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 24, 2026

Structural basis for emetine inhibition of ribosome translocation in Toxoplasma gondii

Wenzhao Dong, Fengrong Wang, Brenna A Saladin…·Jailson Brito Querido

This paper determines the structure of Toxoplasma gondii ribosomes bound to mRNA and tRNA, revealing how emetine inhibits translation by disrupting mRNA translocation.

DOI 10.64898/2026.07.23.740346

experimental assay

𝕏 PostBluesky

Molecular BiologyJournal of Biological ChemistryPeer-reviewedFeb 13, 2026

Human Pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex to repress mRNAs

Elise B. Dunshee, Brenna A Saladin, David J. Turner…·Aaron C. Goldstrohm

The paper identifies how human PUM proteins repress mRNAs by using fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex through their intrinsically disordered RD3 domain.

1 citation

humanexperimental assay

𝕏 PostBluesky