Author

Ishita Purwar

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Amy Krans· 2 shared Clare M. WielandiD· 2 shared Erinn L. Laimon-Thomson· 2 shared Peter K. ToddiD· 2 shared Adrian M. IsaacsiD· 1 shared Amanda L. GarneriD· 1 shared Anna Mae DiehliD· 1 shared Anuprova Bhowmik· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Amy Krans

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis for repeat-associated non-AUG translation initiation on C9orf72 mRNA

Ross T. Kaufhold, Wenzhao Dong, Ishita Purwar, Brenna A Saladin, Clare M. Wieland, Amy Krans, Erinn L. Laimon-Thomson, Indranil Malik, Suada Leskaj, Tal Havilio, Masaaki Sokabe, Christopher S. Fraser, Peter K. Todd, Jailson Brito Querido

The paper determines the structure of C9orf72 RAN translation initiation complexes and identifies a key RNA-RNA interaction that drives DPR production, suggesting a therapeutic target.

bioRxiv · Oct 28, 2026 · PreprintMolecular Biology

Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation

Clare M. Wieland, Shannon E. Wright, Sydney Willey, Ishita Purwar, Samantha Grudzien, Amy Krans, Erinn L. Laimon-Thomson, Melissa J. Asher, Adrian M. Isaacs, Amanda L. Garner, Peter K. Todd

The paper shows that neurons prefer cap-independent RAN translation from specific repeats, linked to altered start codon stringency and eIF1 redistribution.

Nucleic Acids Research · Sep 7, 2026Peer-reviewedNeuroscience

Dysregulated RNA splicing induces regeneration failure in alcohol-associated liver disease

Ullas Valiya Chembazhi, Sushant Bangru, Rajesh Kumar Dutta, Diptatanu Das, Brandon J. Peiffer, Subhashis Natua, Katelyn Toohill, Aurelia Leona, Ishita Purwar, Anuprova Bhowmik, Yogesh Goyal, Zhaoli Sun, Anna Mae Diehl, Auinash Kalsotra

The paper identifies dysregulated RNA splicing in alcohol-associated liver disease as a cause of regeneration failure, highlighting ESRP2 deficiency and its impact on key signaling pathways.

bioRxiv · Nov 29, 2024 · PreprintMolecular Biology