Jailson Brito Querido

The paper determines the structure of C9orf72 RAN translation initiation complexes and identifies a key RNA-RNA interaction that drives DPR production, suggesting a therapeutic target.

This paper determines the structure of Toxoplasma gondii ribosomes bound to mRNA and tRNA, revealing how emetine inhibits translation by disrupting mRNA translocation.

SPIDR is a high-throughput method for mapping RNA-protein interactions that identifies 4EBP1's role in selectively repressing mRNA translation under mTOR inhibition.

This study determines the structure of Pdcd4 bound to the 40S ribosomal subunit, revealing its binding site and mechanism in translational control.

The paper describes the structure of a human 48S initiation complex, revealing a second eIF4A helicase at the mRNA entry site that unwinds secondary structure downstream of the scanning complex.

The paper determines the structure of the 43S PIC from Trypanosoma cruzi and identifies structural differences in translation initiation compared to mammalian hosts.