Author

Alexandra Hart

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Aldo S. BaderiD· 1 shared Andreas VillungeriD· 1 shared Chen Gang GohiD· 1 shared Eloise G. LloydiD· 1 shared Fadia Bou-Dagher· 1 shared Giulia BiffiiD· 1 shared Glenn Robert MassoniD· 1 shared Hlib RazumkoviD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aldo S. BaderORCID

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1 paper

Recent·Most cited

WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2

Jordan Wilson, Jiayi Zhu, Vanesa Vinciauskaite, Eloise G. Lloyd, Simon C.C. Lam, Alexandra Hart, Chen Gang Goh, Fadia Bou-Dagher, Hlib Razumkov, Lena Kobel, Zacharias Kontarakis, John Fielden, Moritz F. Schlapansky, Joanna I. Loizou, Andreas Villunger, , Stephen P. Jackson

This study shows WEE1 inhibitors work better with mRNA translation defects by activating GCN2, and suggests ways to reduce off-target effects.

Nature Communications · Oct 9, 2025Peer-reviewedCancer Biology