Iva Filipovic

The mitochondrial transaminase GOT2 supports Japanese encephalitis virus replication in neuronal cells

This study identifies the mitochondrial transaminase GOT2 as a metabolic dependency of JEV and a potential host-directed antiviral target through integrated transcriptomics and proteomics analyses.

Integrated Clinical and Proteomic Precision Subgrouping for Severe Dengue Endotype Signature

The paper identifies molecular signatures and endotypes in severe dengue by integrating clinical and proteomic data, revealing immune pathways associated with severe disease.

Type I IFN reprograms CD4⁺ T cell lipid metabolism as an antiviral effector mechanism during acute HIV/SIV infection

The paper investigates how type I IFN reprograms CD4⁺ T cell lipid metabolism during acute HIV/SIV infection and identifies metabolic changes linked to viral reservoir establishment.

Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver Fibrosis

This study shows that Jag1 deficiency in a mouse model of Alagille syndrome leads to impaired liver fibrosis due to defective T cell differentiation and hepatocyte maturation.