Shan Jiang

The transcription factor THAP11 is a general regulator of early embryonic polarization

This study identifies THAP11 as a general regulator of early embryonic polarization across three developmental stages in mice, showing its role in cell fate and morphogenesis.

The Y chromosome gene KDM5D restrains CD8+ T cell antitumor immunity through TCR and cholesterol-exhaustion programs

This study identifies KDM5D on the Y chromosome as a suppressor of CD8+ T cell antitumor immunity in males, linking it to TCR and cholesterol-exhaustion programs.

Rescue schizophrenia-related phenotypes caused by Setd1a deficiency by histone demethylase inhibitors

This study identifies TAK-418 as a histone demethylase inhibitor that rescues schizophrenia-like phenotypes in Setd1a-deficient mice by restoring H3K4me3 levels and gene expression.

NFYA regulates spermatogenesis through multifaceted chromatin interactions

This study uses a novel in vivo protein-degradation approach to show NFYA is essential for spermatogenesis by regulating stage-specific transcriptional programs through chromatin interactions.

NFYA regulates two sequential genome-wide transcriptional activation events during oocyte-to-embryo transition

This study identifies NFYA as a regulator of two sequential transcriptional activation events during oocyte-to-embryo transition, showing its role in primordial follicle activation and zygotic genome activation.

ggalign: Bridging the Grammar of Graphics and Biological Multilayered Complexity

ggalign provides a flexible R package for creating composable visualizations of complex, multi-dimensional biological data using layout options and annotation features.

Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in human and mice

The paper identifies dysfunction of the paraventricular hypothalamic nucleus (PVH) as a cause of hypersomnia in humans and mice through neural activity and behavioral studies.