Yixuan Guo

The paper shows how developmental gene silencing is established in zebrafish embryos through H2Aub1 deposition by Rnf2-PRC1, followed by Aebp2-PRC2 recruitment and H3K27me3 deposition.

This study uses reciprocal zebrafish-medaka hybrids to show that maternal factors primarily control the timing of zygotic genome activation.

The paper identifies maternally-deposited antisense piRNAs that silence transposons in zebrafish embryos by targeting young LTR retrotransposons and promoting H3K9me2/3 modification.

The paper shows zebrafish primordial germ cells use germ plasm in two phases to regulate transcriptome divergence from somatic cells through post-transcriptional mechanisms and chromatin changes.