Author

Candice L. Wike

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Organism:zebrafish· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

Bradley Robert CairnsiD· 4 shared Patrick J. MurphyiD· 2 shared Yixuan GuoiD· 2 shared Andrea PauliiD· 1 shared Atsuko Shimada· 1 shared Cody R. James· 1 shared Edward J. GrowiD· 1 shared Erez Lieberman AideniD· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersDevelopmental Biology

Bradley Robert CairnsORCID

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4 papers

Recent·Most cited

Establishment of Developmental Gene Silencing by Ordered Polycomb Complex Recruitment in Early Zebrafish Embryos

Graham Hickey, Candice L. Wike, Xichen Nie, Yixuan Guo, Mengyao Tan, Patrick J. Murphy, Bradley Robert Cairns

The paper shows how developmental gene silencing is established in zebrafish embryos through H2Aub1 deposition by Rnf2-PRC1, followed by Aebp2-PRC2 recruitment and H3K27me3 deposition.

eLife · Jan 4, 2022Peer-reviewedMolecular Biology

Maternally-inherited anti-sense piRNAs antagonize transposon expression in teleost embryos

Yixuan Guo, Krista R. Gert, Svetlana Lebedeva, Magdalena E. Potok, Candice L. Wike, Edward J. Grow, René F. Ketting, Andrea Pauli, Bradley Robert Cairns

The paper identifies maternally-deposited antisense piRNAs that silence transposons in zebrafish embryos by targeting young LTR retrotransposons and promoting H3K9me2/3 modification.

bioRxiv · Nov 3, 2021 · PreprintDevelopmental Biology

CTCF looping is established during gastrulation in medaka embryos

Ryohei Nakamura, Yuichi Motai, Masahiko Kumagai, Candice L. Wike, Haruyo Nishiyama, Yoichiro Nakatani, Neva C. Durand, Kaori Kondo, Takashi Kondo, Tatsuya Tsukahara, Atsuko Shimada, Bradley Robert Cairns, Erez Lieberman Aiden, Shinichi Morishita, Hiroyuki Takeda

The paper examines genome architecture changes during medaka gastrulation, finding that CTCF loops form while CTCF binding sites remain fixed, and transcription precedes mature domain formation.

Genome Research · Jun 1, 2021Peer-reviewedGenomics

Placeholder nucleosomes underlie germline-to-embryo DNA methylation reprogramming

Patrick J. Murphy, Shan Fu Wu, Cody R. James, Candice L. Wike, Bradley Robert Cairns

The paper identifies Placeholder nucleosomes in zebrafish that prevent DNA methylation and regulate gene activation during early embryonic development.

Cell · Feb 1, 2018Peer-reviewedDevelopmental Biology