Elizabeth D. Larson

The paper identifies two distinct DNA-binding domains in Zelda that regulate its tissue-specific chromatin occupancy in Drosophila embryos and neuroblasts.

This study shows that pioneer-factor activity depends on chromatin occupancy and is influenced by protein-intrinsic and cell-type-specific factors.

The paper shows that low-level H3K27me3 enrichment by FruC fine-tunes stemness gene transcription in fly neural stem cells, with conserved mechanisms in humans.

The paper shows that premature translation of Zelda, a zygotic genome activator, does not lead to early gene expression, highlighting the need for coordinated developmental processes.

The paper shows Zelda, a pioneer factor, works with Notch to maintain neuroblasts undifferentiated and reprograms progenitor cells, but its function is limited by repressors and depends on chromatin accessibility and cofactors.

The paper identifies GAF as a maternally encoded factor essential for zygotic genome activation and chromatin accessibility during the maternal-to-zygotic transition in Drosophila.

This study identifies a conserved maternal-specific repressive domain in Zelda that is essential for maternal functions but not zygotic functions during the maternal-to-zygotic transition in Drosophila.