Danielle C. Hamm

The paper identifies a specific D4Z4 sequence that can epigenetically silence a reporter gene, revealing key regulators and mechanisms of DUX4 repression in skeletal muscle.

The paper shows Zelda, a pioneer factor, works with Notch to maintain neuroblasts undifferentiated and reprograms progenitor cells, but its function is limited by repressors and depends on chromatin accessibility and cofactors.

This study identifies a conserved maternal-specific repressive domain in Zelda that is essential for maternal functions but not zygotic functions during the maternal-to-zygotic transition in Drosophila.