Localization of the pioneer factor GAF to subnuclear foci is driven by DNA binding and required to silence satellite repeat expression
Marissa M Gaskill, Isabella V Soluri, Annemarie E. Branks, Alan P. Boka, Michael R. Stadler, Katherine J. Vietor, Hao-Yu S. Huang, Tyler J. Gibson, Mustafa Mir, Shelby A. Blythe, Melissa M. Harrison
This study shows that the pioneer factor GAF localizes to subnuclear foci through binding to GA-satellite repeats, which is necessary for forming heterochromatin and silencing satellite repeat expression.
bioRxiv · Nov 29, 2022 · PreprintDevelopmental Biology