Cheng‐Yu Lee

The paper identifies a conserved profibrotic transitional state arising from alveolar and airway progenitors in fibrosis and shows its epigenetic regulation.

The paper identifies two distinct DNA-binding domains in Zelda that regulate its tissue-specific chromatin occupancy in Drosophila embryos and neuroblasts.

The paper identifies a double-assurance mechanism in Drosophila neuroblasts that regulates the generation of high-potential transit-amplifying progenitors.

The paper identifies Usp5 as a key interactor of Brat that facilitates pre-complex assembly for mRNA degradation during differentiation in Drosophila.

The paper shows that low-level H3K27me3 enrichment by FruC fine-tunes stemness gene transcription in fly neural stem cells, with conserved mechanisms in humans.

The paper shows that premature translation of Zelda, a zygotic genome activator, does not lead to early gene expression, highlighting the need for coordinated developmental processes.

The paper shows Zelda, a pioneer factor, works with Notch to maintain neuroblasts undifferentiated and reprograms progenitor cells, but its function is limited by repressors and depends on chromatin accessibility and cofactors.

This study shows that me31B prevents excessive dedifferentiation of spermatogonia into germline stem cells in Drosophila, maintaining stem cell homeostasis by regulating nos.

The paper uses targeted scRNA-seq and multi-informatic analysis to characterize neural differentiation in Drosophila brain neuroblast lineages and provides a visualization tool for gene function curation.

This study shows that Cullin3 enhances aPKC activity to localize Numb at the basal cortex, promoting differentiation of Drosophila neural stem cell progeny by downregulating Notch signaling.

The paper identifies Tailless as a master regulator maintaining neuroblast identity and shows its inactivation stabilizes intermediate progenitor commitment during neurogenesis.