John C. Marecki

This study identifies a two-pronged mechanism by which CMX521 inhibits SARS-CoV-2 RNA-dependent RNA polymerase through biochemical assays and single-molecule techniques.

This study shows that the coronavirus helicase enhances RNA synthesis through duplex RNA by tenfold by forming a directional complex with the polymerase, revealing an active coupling mechanism that modulates replication dynamics.

This study shows that coronavirus polymerase template switching is driven by nsp13-helicase and is enhanced by remdesivir and molnupiravir, leading to defective RNA production.

The paper shows that the SARS-CoV-2 polymerase core RTC undergoes a conformational change after RNA binding to become elongation-competent, which is essential for viral RNA synthesis.

The paper investigates how RNA-RNA interactions in viral replication are controlled by biomolecular condensates, showing that sequence complementarity and condensate properties influence RNA organization.