Flavia Stal Papini

This paper introduces a multimodal platform combining magnetic tweezers and TIRF for high-throughput single-molecule analysis, enabling real-time, parallel measurements of force, torque, fluorescence, and temperature.

This study evaluates the antimicrobial activity of ThymoQuin, finding it selectively modulates gut microbiota at intermediate concentrations but shows broader effects at higher doses.

This paper develops an in-situ force calibration method for magnetic tweezers and uses it to reveal how MTERF1 causes directional transcription termination through DNA unwinding and a kinetic barrier.

This study shows that the coronavirus helicase enhances RNA synthesis through duplex RNA by tenfold by forming a directional complex with the polymerase, revealing an active coupling mechanism that modulates replication dynamics.

This study shows that coronavirus polymerase template switching is driven by nsp13-helicase and is enhanced by remdesivir and molnupiravir, leading to defective RNA production.

The paper shows that the SARS-CoV-2 polymerase core RTC undergoes a conformational change after RNA binding to become elongation-competent, which is essential for viral RNA synthesis.

This study shows MDA5 compacts dsRNA via ATP-dependent loop extrusion, stabilizing the structure through CARD domain oligomerization.