Fulvio Chiacchiera

The paper introduces HiCONA, a Bayesian framework that identifies mitotically preserved chromatin interactions guiding post-mitotic 3D genome reassembly and epigenetic memory.

The paper identifies TGF-β-driven extracellular matrix remodeling in vascular leptomeningeal-like cells as a driver of neurodegeneration in PSP-RS, showing therapeutic potential through pharmacological inhibition.

This study shows RA signaling promotes luminal identity in prostate progenitors through Foxa1, and identifies a loss-of-function mutation in Foxa1 linked to prostate cancer dedifferentiation.