Author

Lisanne I Knol

University of EdinburghORCID 0000-0002-8975-0398Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Alasdair C. IvensiD· 2 shared Ana Gázquez-GutiérreziD· 2 shared Guillermo PerisiD· 2 shared Katrina GordoniD· 2 shared Pablo Tristán-RamosiD· 2 shared Priscilla Chin· 2 shared Sara MacíasiD· 2 shared Sara R. HerasiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersMolecular Biology

Alasdair C. IvensORCID

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3 papers

Recent·Most cited

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8

Ana Gázquez-Gutiérrez, Priscilla Chin, Guillermo Peris, Katrina Gordon, Pilar G. Marchante, Jeroen Witteveldt, Pablo Tristán-Ramos, Jérôme O. Rouvière, Lisanne I Knol, Alasdair C. Ivens, Lourdes López-Onieva, Antonio M. Estévez, William Garland, Torben Heick Jensen, Sara R. Heras, Sara Macías

This study shows DGCR8 suppresses endogenous dsRNA from TEs to prevent IFN response activation, with implications for 22qDS.

Nucleic Acids Research · Feb 20, 2026Peer-reviewedMolecular Biology

Fatty Acid Synthase associates with nuclear-derived cytoplasmic dsRNA molecules and influences antiviral innate immune response

Charline Pasquier, Mélanie Messmer, Lise Moroge, Lisanne I Knol, Johana Chicher, Richard Patryk Ngondo, Sébastien Pfeffer, Erika Girardi

This study shows FASN depletion increases cytoplasmic endogenous dsRNA and enhances antiviral innate immune responses.

bioRxiv · Jul 16, 2025 · PreprintImmunology

DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects

Ana Colomer-Boronat, Lisanne I Knol, Guillermo Peris, Laura Sánchez, Silvia Peluso, Pablo Tristán-Ramos, Ana Gázquez-Gutiérrez, Priscilla Chin, Katrina Gordon, Guillermo Barturen, Robert E. Hill, Francisco Jose Sanchez-Luque, Jose Luis Garcia-Perez, Alasdair C. Ivens, Sara Macías, Sara R. Heras

This study shows that DGCR8 haploinsufficiency in human pluripotent cells causes RNA dysregulation and pluripotency defects, with rescue by primate-specific miRNAs.

Nucleic Acids Research · Mar 20, 2025Peer-reviewedMolecular Biology