Author

Alejandro Rubio-Roldán

Universidad de GranadaORCID 0000-0002-6775-4013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Etienne GuichardiD· 2 shared Gaël CristofariiD· 2 shared Jose Luis Garcia-PereziD· 2 shared Laura SáncheziD· 2 shared Sara R. HerasiD· 2 shared Adam D. EwingiD· 1 shared Alessio BoattiniiD· 1 shared Ángela MaciaiD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenomics

Etienne GuichardORCID

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3 papers

Recent·Most cited

The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

Pablo Tristán-Ramos, Alejandro Rubio-Roldán, Guillermo Peris, Laura Sánchez, Suyapa Amador‐Cubero, Sébastien Viollet, Gaël Cristofari, Sara R. Heras

This study shows that let-7 microRNA reduces LINE-1 retrotransposition by inhibiting ORF2p translation in human lung cancer.

Nature Communications · Nov 11, 2020Peer-reviewedMolecular Biology

LINE-1 retrotransposition impacts the genome of human pre implantation embryos and extraembryonic tissues

Martín Muñoz-López, Raquel Vilar, Claude Philippe, Raheleh Rahbari, Sandra R. Richardson, Miguel Andrés-Antón, Thomas J. Widmann, David Cano, José Luis Cortés, Alejandro Rubio-Roldán, Etienne Guichard, Sara R. Heras, Francisco Jose Sanchez-Luque, Maria H. Morell, Elisabet Aguilar, , Jose Luis Garcia-Perez

This study shows LINE-1 retrotransposition occurs in human pre-implantation embryos and extraembryonic tissues, impacting gene expression and potentially contributing to genomic variation.

bioRxiv · Jan 18, 2019 · PreprintGenomics

Impact of non-LTR retrotransposons in the differentiation and evolution of Anatomically Modern Humans

Etienne Guichard, Valentina Peona, Guidantonio Malagoli Tagliazucchi, Lucia Abitante, Evelyn Jagoda, Margherita Musella, Marco Ricci, Alejandro Rubio-Roldán, Stefania Sarno, Donata Luiselli, Davide Pettener, Cristian Taccioli, Luca Pagani, Jose Luis Garcia-Perez, Alessio Boattini

This study identifies human-specific non-LTR retrotransposon insertions and shows their association with gene expression changes and phenotypic evolution in humans.

Mobile DNA · Aug 15, 2018Peer-reviewedGenomics