Michele Tinti

The paper uses MOT-library profiling to assess all possible mutations at a drug binding site and predicts resistance mechanisms through computational modeling.

This paper identifies ZNK1 as a zinc-sensing RNA-binding protein in trypanosomes that degrades ZIP3 mRNA in response to zinc availability.

This study identifies temperature-sensitive mRNA structures and shows that argonaute-dependent transcriptome remodelling mediates thermo-sensing in trypanosomes.

This paper identifies mutations in the gamma subunit of the mitochondrial ATP synthase in Trypanosoma brucei that lead to kinetoplast loss and drug resistance.

The paper identifies mutations in trypanosome CPSF3 that confer resistance to acoziborole, a drug targeting RNA processing, and explains the molecular mechanism of resistance through computational modeling.

The paper identifies and characterizes Cryptosporidium Oocyst Wall Proteins (COWPs), showing that COWP8 maintains the structural integrity of the oocyst wall without affecting viability or chlorination resistance.

The paper shows that VSG transcripts play a non-coding role in allelic exclusion in trypanosomes by participating in allelic competition.

The paper shows that specific histone H4 lysine mutations disrupt polycistronic gene expression in trypanosomes by altering promoter-associated chromatin structure.

This study creates a tissue atlas of Cryptosporidium parvum infection in neonatal calves and immunocompromised mice to compare infection patterns and host-parasite interactions.

The paper introduces a CRISPR/Cas9-based protein tagging system for Kinetoplastids that preserves endogenous regulatory elements and demonstrates its utility in studying gene regulation.

The paper evaluates and optimizes sequence-based gene regulatory deep learning models using a DREAM Challenge dataset, showing improvements through architectural and training strategy refinements.

This study shows TbFUT1 is essential for mitochondrial FoF1-ATP synthase assembly in Trypanosoma brucei by affecting subunit levels and kDNA replication.

The paper performs a genome-wide RNAi screen in Trypanosoma brucei to identify cell cycle regulators, identifying hundreds of proteins involved in different stages of the cell cycle and providing functional genomic insights.