Genetic Drivers of Sensitivity or Resistance to RAS(ON) Multi-Selective Inhibitors in NRAS-Mutated Melanoma
Mona Foth, Wontak Kim, Kayla T. O’Toole, Brandon Murphy, Montserrat Justo-Garrido, Sanjana Srinivas Boggaram, Phaedra C. Ghazi, Euan Brennan, M. Isaac Wright, Tate Shepherd, Emilio Cortes-Sanchez, Yingyun Wang, Jennifer A. Roth, Matthew G. Rees, Melissa M. Ronan, , Martin McMahon
This study identifies RAS(ON) inhibitors effective against NRAS-mutated melanoma and reveals resistance mechanisms through Ppia and Map2k1 mutations.
Cancer Research · May 22, 2026Peer-reviewedCancer Biology