This study examines the effects of a single rapamycin dose on brain glucose metabolism and synaptic density in rats using PET imaging, finding increased metabolism and decreased synaptic density.

bioRxiv · Mar 11, 2025 · PreprintNeuroscience

Mapping whole brain effects of infrared neural stimulation with positron emission tomography

Marcello Meneghetti, Frederik Gudmundsen, Naja Støckel Jessen, Kunyang Sui, Christina Baun, Mikael Palner, Christos Markos

This study uses FDG-PET imaging during infrared neural stimulation to map whole-brain metabolic responses and identify multi-circuit connections in cortical and subcortical regions.

Imaging Neuroscience · Dec 1, 2023Peer-reviewedNeuroscience

Synaptic density and neuronal metabolic function measured by PET in the unilateral 6-OHDA rat model of Parkinson's disease

Nakul Ravi Raval, Frederik Gudmundsen, Morten Juhl, Ida Vang Andersen, Nikolaj Speth, Annesofie Videbæk, Ida Nymann Petersen, Jens Damsgaard Mikkelsen, Patrick M. Fisher, Matthias M. Herth, Pontus Plavén‐Sigray, Gitte M. Knudsen, Mikael Palner

This study compares [11C]UCB-J and [18F]FDG PET in a 6-OHDA rat model of Parkinson's disease, finding divergent changes in synaptic density and metabolic function in CSTC circuits.

Frontiers in Synaptic Neuroscience · Nov 18, 2021Peer-reviewedNeuroscience

Dorsal striatal dopamine induces fronto-cortical hypoactivity and implies reduced anxiety and compulsive behaviors in rats

Agata Casado-Sainz, Frederik Gudmundsen, Simone Larsen Bærentzen, Denise Lange, Annemette Ringsted, Isabel Martinez Tejada, Siria Medina, Hedok Lee, Claus Svarer, Sune Høgild Keller, Martin Schain, Celia Kjærby, Patrick M. Fisher, Paul D. Cumming, Mikael Palner

The paper investigates the effects of dorsal striatal dopamine activation on CSTC circuit function in rats, finding reduced fronto-cortical activity and changes in behaviors related to anxiety and compulsive actions.

bioRxiv · Feb 11, 2021 · PreprintNeuroscience