Valentina Proserpio

This study validates allele-specific LMNB1 silencing in patient-derived astrocytes as a therapeutic approach for ADLD by showing restored physiological levels and functional improvements.

The paper shows that brain injury reactivates a developmental program in astrocytes to generate transient LGE-class interneurons that integrate into neural circuits.

This study develops a 3D model of human pluripotent epiblast formation and shows that TGF-beta dynamically maintains epithelial identity, independent of canonical pluripotency markers.

The paper curates a database of RNA-DNA binding sites and introduces a tool to predict RNA:DNA:DNA triple helices, showing most lncRNAs can bind the genome via this mechanism.