Ivan Molineris

Brain injury reactivates a developmental program driving genesis and integration of transient LGE-class interneurons

The paper shows that brain injury reactivates a developmental program in astrocytes to generate transient LGE-class interneurons that integrate into neural circuits.

Ohno-miRNAs: intragenic miRNA pairs derived from whole-genome duplication

The paper identifies Ohno-miRNAs, intragenic miRNA pairs from whole-genome duplication, and shows they have higher retention rates, sequence similarity, and regulate common targets compared to SSD miRNAs.

Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer PDXs

The paper trains an ensemble classifier to predict cetuximab sensitivity in colorectal cancer PDXs using multi-omic data, achieving high accuracy and demonstrating its utility for therapeutic biomarker development.

FVIII interacts with cell surface to regulate endothelial cell functionality

This study shows FVIII regulates endothelial cell functionality and vessel stability, with therapeutic potential in haemophilia A.

Nr2f1 controls mitochondrial dynamics in mouse adult-born hippocampal neurons

This study shows Nr2f1 regulates mitochondrial dynamics in adult-born hippocampal neurons, linking it to BBSOAS pathogenesis.

RNABSdb and 3plex enable deep computational investigation of triplex forming lncRNAs

The paper curates a database of RNA-DNA binding sites and introduces a tool to predict RNA:DNA:DNA triple helices, showing most lncRNAs can bind the genome via this mechanism.

Patterns of cancer somatic mutations predict genes involved in phenotypic abnormalities and genetic diseases

The paper uses somatic mutation patterns from cancer to predict genes involved in phenotypic abnormalities and genetic diseases, showing their predictive power is independent of germline-based methods.