David L. Paterson

The paper develops a rules-based classifier to predict ciprofloxacin resistance in Klebsiella pneumoniae from genotype data and demonstrates its global distribution association with quinolone consumption.

This study identifies two mechanisms of cefiderocol resistance in Acinetobacter baumannii: cAMP signalling disruption and Hfq RNA-binding domain truncation, both linked to iron homeostasis and reduced drug activity.

The paper identifies a new carbapenem-resistant E. coli clone, ST361, associated with UTI and shows its virulence is linked to surface polysaccharides and mobile genetic elements.

This study analyzes the spread of blaOXA-181-producing bacteria in Australia, finding that the IncX3 plasmid is highly stable with minimal genetic variation, suggesting that genomic similarity does not necessarily indicate recent transmission.

This study identifies emerging resistance in KPC variants of K. pneumoniae to CZA, FDC, and FPZ, with mutations in specific regions linked to collateral resistance.

This paper benchmarks six microbial SNP calling pipelines using multiple datasets, highlighting the variability in performance and the need for standardized benchmarking.

MicroPIPE constructs high-quality bacterial genomes using ONT and Illumina sequencing with an automated pipeline.

The paper analyzes DNA methylation patterns in seven Escherichia coli ST101 strains to identify methylome diversity linked to mobile genetic elements and their impact on functional differences between nearly identical isolates.

This study characterizes the genomic context of blaNDM-1 in E. coli ST101 isolates using long-read sequencing, revealing two clades with distinct resistance profiles and plasmid-mediated blaNDM-1 carriage mechanisms.

The paper uses three whole genome sequencing technologies to analyze a carbapenemase-producing Enterobacter hormaechei outbreak, identifying transmission dynamics and plasmid context.