Scott A. Beatson

OXA-181 transmission confounded by a stable IncX3 plasmid

This study analyzes the spread of blaOXA-181-producing bacteria in Australia, finding that the IncX3 plasmid is highly stable with minimal genetic variation, suggesting that genomic similarity does not necessarily indicate recent transmission.

Systematic benchmarking of all-in-one microbial SNP calling pipelines

This paper benchmarks six microbial SNP calling pipelines using multiple datasets, highlighting the variability in performance and the need for standardized benchmarking.

MicroPIPE: An end-to-end solution for high-quality complete bacterial genome construction

MicroPIPE constructs high-quality bacterial genomes using ONT and Illumina sequencing with an automated pipeline.

Strain and lineage-level methylome heterogeneity in the multi-drug resistant pathogenic Escherichia coli ST101 clone

The paper analyzes DNA methylation patterns in seven Escherichia coli ST101 strains to identify methylome diversity linked to mobile genetic elements and their impact on functional differences between nearly identical isolates.

Genomic characterisation and context of the blaNDM-1 carbapenemase in Escherichia coli ST101.

This study characterizes the genomic context of blaNDM-1 in E. coli ST101 isolates using long-read sequencing, revealing two clades with distinct resistance profiles and plasmid-mediated blaNDM-1 carriage mechanisms.

The evolution of nitroimidazole antibiotic resistance in Mycobacterium tuberculosis

This study identifies mutations in Mycobacterium tuberculosis that confer resistance to nitroimidazole antibiotics, highlighting the need for monitoring these mutations to manage antibiotic use.

Integrating multiple genomic technologies to investigate an outbreak of carbapenemase-producing Enterobacter hormaechei

The paper uses three whole genome sequencing technologies to analyze a carbapenemase-producing Enterobacter hormaechei outbreak, identifying transmission dynamics and plasmid context.

Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre

The paper uses whole genome sequencing to show that M3L7, a multidrug-resistant sub-type of AUST-02, emerged as a shared strain among CF patients in a single centre, with evidence of both continuous infection and cross-infection.

Microevolution of aquatic Streptococcus agalactiae ST-261 from Australia indicates dissemination via imported tilapia and ongoing adaptation to marine hosts or environment

The paper traces the evolution of Streptococcus agalactiae ST-261 isolates, showing their dissemination via imported tilapia and adaptation to marine environments.

SMRT sequencing reveals differential patterns of methylation in two O111:H- Shiga toxigenic Escherichia coli isolates from a historic hemolytic uremic syndrome outbreak in Australia

This study uses SMRT sequencing to compare the methylome of two STEC isolates, identifying differential methylation patterns linked to regulatory differences.