Author

Karen Julie la Cour Karottki

Novo Nordisk FoundationORCID 0000-0001-5631-6694Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Gyun Min LeeiD· 3 shared Helene Faustrup KildegaardiD· 3 shared Hooman HefziiD· 3 shared Nathan E. LewisiD· 3 shared Anders Holmgaard HanseniD· 2 shared Kai XiongiD· 2 shared Shangzhong LiiD· 2 shared Alejandro Gómez ToledoiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenomics

Gyun Min LeeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BioengineeringNature MetabolismPeer-reviewedJan 14, 2025

Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells

Hooman Hefzi, Iván Martínez‐Monge, Igor Marín de Mas…·Nathan E. Lewis

This study eliminates the Warburg Effect in mammalian cells by knocking out lactate dehydrogenase and feedback regulators, maintaining growth rate while reducing lactate production.

28 citationstop 2%

mousehuman

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GenomicsCell Reports MethodsPeer-reviewedAug 1, 2021

Using targeted genome integration for virus-free genome-wide mammalian CRISPR screen

Kai Xiong, Karen Julie la Cour Karottki, Hooman Hefzi…·Lasse Ebdrup Pedersen

This paper develops a virus-free CRISPR screening platform for CHO cells, identifying 338 essential genes and 76 genes involved in ER stress.

38 citations

mouseCRISPR screen

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GenomicsNAR Genomics and BioinformaticsPeer-reviewedJun 23, 2021

A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells

Isaac Shamie, Sascha H. C. Duttke, Karen Julie la Cour Karottki…·Nathan E. Lewis

The paper revises transcription start site annotations in Chinese hamster genes using experimental data to improve gene engineering and glycosylation in CHO cells.

16 citations

mouseexperimental assay

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