Yu Shyr

This study sequenced 35,024 individuals with predominantly African ancestry to address gaps in genomics and healthcare, finding under-documented disease variants and novel associations with drug adverse events and glycemic control.

The paper identifies a novel epithelial cell type, LND, in Crohn's disease that is associated with immune dysregulation and disease activity.

aKNNO improves clustering of both abundant and rare cell types in single-cell and spatial transcriptomics data by using an optimized adaptive k-nearest neighbor graph.

SpaGene finds spatial expression patterns without assuming a model, reportedly with more power and better scaling than existing methods, and extends to ligand-receptor colocalization.

This paper introduces sc-UniFrac, a framework to quantify compositional diversity in cell populations across single-cell transcriptome datasets, demonstrating its utility in various applications.

The paper introduces TIGER, a pipeline for analyzing extracellular small RNAs, demonstrating its ability to identify sRNAs on lipoproteins and in biofluids with high accuracy.