Ronald Anthony DePinho

The Y chromosome gene KDM5D restrains CD8+ T cell antitumor immunity through TCR and cholesterol-exhaustion programs

This study identifies KDM5D on the Y chromosome as a suppressor of CD8+ T cell antitumor immunity in males, linking it to TCR and cholesterol-exhaustion programs.

Therapeutic targeting of Syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

This study identifies the YAP1-SDC1 axis as a driver of resistance to mKRAS inhibitors in gastrointestinal cancers and suggests targeting this axis to overcome resistance.

Epigenetic Control of TERRA by FTSJ3 is Critical for Telomerase-Driven Cancers

The paper identifies FTSJ3 as a critical vulnerability in hTERT-overexpressing cancers by showing its role in TERRA methylation and telomeric heterochromatin stability.

Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids

This study identifies major sources of transcriptomic variation in human intestinal organoids, showing that culture methods like substrate and format have large effects compared to experimental manipulations.