Avijit Mallick

The paper identifies a signaling pathway linking endosomal recycling impairment to activation of the mitochondrial unfolded protein response, promoting extracellular proteostasis.

This study shows that LONP-1 deficiency disrupts mitochondrial protein synthesis and DNA replication in C. elegans, which is partially restored by mutations in mitochondrial ribosome proteins.

The paper identifies NHR-180 as a regulator of mitochondrial function and protein synthesis that can restore mitochondrial function in atfs-1(null) worms and mammalian models.

This study identifies genes that suppress the effects of pry-1 mutations in C. elegans, revealing their roles in reproductive development, stress response, and aging.

This study identifies picd-1 as an interacting gene of pry-1 in C. elegans, showing its role in stress response and lifespan regulation through inhibition of CRTC-1 function.