Author

Carlos Alberto de Carvalho Fraga

Universidade Federal de AlagoasORCID 0000-0002-9564-9595Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Helder Imoto NakayaiD· 2 shared Abishek Balachandra VaidyaiD· 1 shared Adam R. MarksiD· 1 shared Alice Oliffson KamphorstiD· 1 shared Amaia LujambioiD· 1 shared An HotterbeekxiD· 1 shared Arvid SulsiD· 1 shared Aurelie Andrzejewski· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Helder Imoto NakayaORCID

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2 papers

Recent·Most cited

Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approaches

My Kieu Ha, Vincent M.L. Van Deuren, Carlos Alberto de Carvalho Fraga, An Hotterbeekx, Joke Dehoorne, Thomas Renson, Elke Geens, Nicolaas E. Aerts, Christiaan H. W. Heusdens, Maria S. Kuznetsova, Margot Van Mechelen, M Vanden Bulcke, Ilse E. A. Hoffman, Ruth Wittoek, Eva De Wachter, , Benson Ogunjimi

The paper creates a synovial fluid TCR, cytokine, and cell repertoire atlas to compare disease mechanisms across arthritic conditions using systems immunology approaches.

bioRxiv · Jan 10, 2025 · PreprintImmunology

ICOS limits memory-like properties and function of exhausted PD-1+ CD8 T cells

Étienne Humblin, Isabel Korpas, Nataliya Prokhnevska, Abishek Balachandra Vaidya, Dan Filipescu, Jiahua Lu, Verena van der Heide, Carlos Alberto de Carvalho Fraga, Tesia Bobrowski, Adam R. Marks, Matthew D. Park, Helder Imoto Nakaya, Emily Bernstein, Brian D. Brown, Amaia Lujambio, , Alice Oliffson Kamphorst

This study shows ICOS limits the function of exhausted PD-1+ CD8 T cells by promoting their differentiation into less functional effector-like cells, and inhibiting ICOS improves anti-tumor responses.

Immunity · Sep 20, 2024Peer-reviewedImmunology