Felicia Lazure

Quinolinic acid phosphoribosyl transferase moonlights as an apoptosis regulator to empower lung cancer progression

This study identifies QPRT as a non-canonical apoptosis regulator in NSCLC that suppresses caspase-3 activation, independent of its role in NAD biosynthesis, suggesting it as a therapeutic target.

A Multiomic Analysis of Cachectic Mice Reveals Cancer Driven Suppression of Muscle Stem Cell Differentiation

This study identifies cancer-driven suppression of muscle stem cell differentiation in cachectic mice through GDF15 and MMP9, revealing a new mechanism of muscle wasting.

Aging directs the differential evolution of KRAS-driven lung adenocarcinoma

This study uses single-cell RNA-sequencing to show that aging promotes KRAS-driven lung adenocarcinoma evolution toward a stem-like state through age-related changes in the tumor microenvironment.

Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche Environment

This study shows that the niche environment significantly influences skeletal muscle stem cell transcriptional activity, with some age-related changes being reversible through exposure to a young niche.

Application of ATAC-Seq for genome-wide analysis of the chromatin state at single myofiber resolution

The paper applies single myofiber ATAC-Seq to analyze chromatin state changes in skeletal muscle under different conditions, revealing differences in chromatin accessibility between resting and regenerating myofibers.

Myf6/MRF4 is a Myogenic Niche Regulator Required for the Maintenance of the Muscle Stem Cell Pool

This study shows that Myf6/MRF4 regulates myokine production and maintains the muscle stem cell pool by controlling signaling pathways like EGFR and STAT3.

High Resolution Genome Wide Expression Analysis of Single Myofibers Using SMART-Seq

This paper develops smfRNA-Seq to analyze the whole transcriptome of individual myofibers and finds aging causes significant changes in metabolic and structural gene expression.