OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency
Laure D. Bernard, Agnès Dubois, Victor Heurtier, Véronique Fischer, Inma González, Almira A. Chervova, Alexandra Tachtsidi, Noa Gil, Nick D. L. Owens, Lawrence E. Bates, Sandrine Vandormael‐Pournin, José Silva, Igor Ulitsky, Michel Cohen‐Tannoudji, Pablo Navarro
The paper identifies a genetic circuitry where OCT4 activates an antisense lncRNA that represses Suv39h1, linking H3K9 methylation levels to pluripotency in mouse ES cells.
Nucleic Acids Research · Jun 28, 2022Peer-reviewedMolecular Biology