Virginia G. Garda

Drug-induced phospholipidosis as an artifact in antiviral drug repurposing

The paper identifies phospholipidosis as a common artifact in antiviral drug repurposing and introduces a microplate-based assay to detect it, finding that 65% of tested drugs induce it.

Phosphorylation State Dictates Bacterial Stressosome Assembly and Function

This study shows phosphorylation at specific residues on stressosome proteins dictates assembly, activation, and function in Listeria monocytogenes, with implications for virulence and antimicrobial targets.

Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models

This study identifies MTK458, a PINK1 activator, which reduces α-synuclein pathology and pUb levels in Parkinson's disease models and correlates plasma pUb with disease progression.