This study investigates the role of IL10 in avian mucosal immunity by generating IL10-deficient chickens, showing altered microbiome composition and enhanced pathogen clearance with increased inflammation.

eLife · Oct 16, 2025Peer-reviewedImmunology

Spatial distribution of poultry farms using point pattern modelling: a method to address livestock environmental impacts and disease transmission risks

Marie-Cécile Dupas, Francesco Pinotti, Chaitanya G. Joshi, Madhvi N. Joshi, Weerapong Thanapongtharm, Madhur Dhingra, Damer P. Blake, Fiona M. Tomley, Marius Gilbert, Guillaume Fournié

This paper develops a farm distribution model to predict poultry farm locations and sizes in data-scarce regions, showing that spatial clustering increases disease transmission risk.

PLoS Computational Biology · Oct 1, 2024Peer-reviewedBioinformatics

Multi-omics analysis reveals regime shifts in the gastrointestinal ecosystem in chickens following anticoccidial vaccination and Eimeria tenella challenge

Po‐Yu Liu, Janie Liaw, Francesca Soutter, José Manuel Jaramillo-Ortiz, Fiona M. Tomley, Dirk Werling, Ozan Gundogdu, Damer P. Blake, Dong Xia

This study uses multi-omics analysis to identify shifts in the chicken gastrointestinal ecosystem following vaccination and Eimeria tenella challenge, revealing distinct metabolic and microbial profiles associated with health, infection, and recovery.

mSystems · Sep 17, 2024Peer-reviewedMicrobiology

EPINEST, an agent-based model to simulate epidemic dynamics in large-scale poultry production and distribution networks

Francesco Pinotti, José Lourenço, Sunetra Gupta, Suman Das Gupta, Joerg Henning, Damer P. Blake, Fiona M. Tomley, Tony Barnett, Dirk Udo Pfeiffer, Md. Ahasanul Hoque, Guillaume Fournié

EPINEST simulates epidemic dynamics in poultry production networks to study pathogen transmission and health hazards.

PLoS Computational Biology · Feb 21, 2024Peer-reviewedBioinformatics