Glutamine-derived NADH fuels lactate production to maximize ATP yield under oxygen consumption constraints in head and neck cancer
Christoff Odendaal, Rianne Dalhuisen, Milou Hoving…·Jurgen R. Haanstra
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Delft University of TechnologyORCID 0000-0003-2199-5070Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
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Christoff Odendaal, Rianne Dalhuisen, Milou Hoving…·Jurgen R. Haanstra
Maaike Remeijer, Christoff Odendaal, Rebeca González‐Cabaleiro, Frank J. Bruggeman
The paper calculates product and ATP yields for glucose fermentation by analyzing a pan-catabolic network of anaerobic digestion, revealing many novel conversions and varying ATP yields.
Frank J. Bruggeman, Maaike Remeijer, Christoff Odendaal, Rebeca González‐Cabaleiro
This paper introduces a computational framework to calculate net conversions in metabolic networks using elementary flux modes and thermodynamic parameters, with applications in microbial ecology and metabolic engineering.
Christoff Odendaal, Marit A Verheijen, Rebeca González‐Cabaleiro
The paper identifies three thermodynamically distinct product profiles in Clostridial fermentation and shows that intermediate ratios require less efficient pathways due to conflicting redox demands.
Christoff Odendaal, Olga Krebs, Barbara M. Bakker
The paper constructs an ensemble of kinetic models of mitochondrial fatty acid oxidation to link residual enzyme activity to clinical symptoms in inherited fatty-acid oxidation deficiencies.
Vanessa Luzak, Esteban Osses, Anna Danese…·T. Nicolai Siegel
The paper uses SLAM-seq and scRNA-seq to show RNA processing and stability independently influence mRNA levels in African trypanosomes.