Yali Bai

cf-Cabernet improves cfDNA methylation sequencing by repairing nicks before end repair, preserving methylation information and outperforming standard methods.

The paper introduces Joint-Cabernet, a single-cell platform for profiling 5hmC and 5mC, and applies it to mouse brain nuclei to study DNA hydroxymethylation changes with aging.

The paper introduces Cabernet, a bisulfite-free single-cell method for high-resolution 5mC and 5hmC profiling, revealing epigenetic dynamics in mouse embryos and demonstrating scalability for complex tissues.

The paper reports the cryo-EM structure of a potent SARS-CoV-2 NAb, BD-368-2, showing it blocks ACE2 binding and induces structural changes in the spike trimer, distinct from other NAbs.