Yuji Ikegaya

This paper introduces HERO, a sonification pipeline that converts neural spike trains into reproducible, event-faithful audio, aiding in the analysis of population activity.

This study shows that ramelteon increases hippocampal ripple occurrence and amplitude during NREM sleep in mice, potentially supporting its cognitive-enhancing effects.

This paper develops enzyme activity-based prodrugs for precision oncology, showing reduced toxicity and improved efficacy in tumor models.

This study shows that right hippocampal ripples increase before insight occurs in humans, suggesting a role in non-conscious processing leading to conscious awareness.

The paper shows that ventral hippocampal neurons in prairie voles encode pair-bonded partner identity nonlinearly through 3-4 Hz oscillations.

The paper shows that CA3 network activity is distributed across mossy cell ensembles with pseudo-orthogonal representations, enabling efficient information compression in the hippocampal MC layer.

The paper investigates how theanine affects neural oscillations in mice during object recognition, finding enhanced theta and beta/gamma oscillations in specific brain regions.

This study shows that Alzheimer's disease mice exhibit age-dependent, odorant-specific changes in olfactory sensitivity, with hyperosmia to esters at 2 months and hyposmia at 4 months.

This paper generates images from rat brain activity using a latent diffusion model, converting continuous neural signals into visual outputs.

This study shows dopamine reduces connectivity in hippocampal networks, leading to more diverse burst patterns in rat neurons.

This study examines how novelty and temporal distance affect post-experience reactivation of hippocampal place cells in rats, showing distinct roles for CA3 and CA1 in processing novelty and temporal aspects of memory.

This study correlates hippocampal sharp-wave ripples with self-generated thoughts in humans using local field potential recordings and experience sampling.

The paper analyzes hippocampal neural activity during a working memory task and finds that trajectory distance and direction change with memory load and SWR events.

The paper examines how LFP oscillations in the mouse olfactory bulb correlate with sniffing during dark and light periods, finding stronger correlations in the dark.

The paper investigates how membrane potential dynamics during hippocampal sharp-wave ripples (SWRs) mature in mice, showing that inhibitory inputs develop to enable precise spike timing during SWRs.

This study shows that aged mice show reduced representation of awake/sleep states in local field potential correlations, which can be partially restored with environmental enrichment.

The paper examines oscillatory activity in the prefrontal cortex and amygdala of mice during social interactions, finding specific frequency changes linked to social behavior and deficits.

The paper shows that using endpoint feedback in a visuomotor task promotes cognitive strategy use, leading to better intermanual transfer of learning compared to continuous feedback.

The paper shows that hippocampal replays prioritize salient experiences and support the reinforcement of new behavioral policies during learning.

The paper defines hippocampal ripples using a semisupervised approach combining Gaussian mixed model clustering and a deep convolutional neural network, achieving 0.72 AUPRC for ripple detection.

This paper introduces HA_time, a hyperacuity algorithm for precise spike timing estimation from calcium imaging, achieving up to 20-fold improvement in spike time precision.

This study demonstrates the application of the auxin-inducible degron system for rapid and reversible protein degradation in hippocampal neurons.

The paper identifies recurrent excitatory monosynaptic connections in the CA2 region of the mouse hippocampus using electrophysiological recordings.

This study investigates neural activity patterns in the mouse piriform cortex during sharp wave events, finding non-random organization and coordinated activation of specific neuron pairs.

This study identifies GABAergic dysfunction in the anterior cingulate cortex as a mechanism underlying social deficits caused by maternal immune activation in mice.