Cadia Chan

Decoding the naked mole-rat genome, telomere to telomere

The paper presents a telomere-to-telomere genome assembly of the naked mole-rat and compares it with a related species to identify gene losses and duplications associated with unique traits.

Early MATR3 loss and distinct neurodegenerative molecular signatures precede the onset of neuropathology in motor neurons and Purkinje cells of MATR3 S85C knock-in mouse model of ALS

Age, sex, and cell type-resolved hypothalamic gene expression across the pubertal transition in mice

The paper analyzes hypothalamic gene expression in mice across puberty, identifying age- and sex-specific changes and their association with pubertal regulation.

Administration of amniotic fluid stem cell extracellular vesicles promotes development of fetal hypoplastic lungs by immunomodulating lung macrophages

Amniotic fluid stem cell extracellular vesicles improve fetal lung development in CDH by modulating macrophage inflammation and restoring normal gene expression.

Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland

This study profiles gene and miRNA expression in mouse pituitaries across postnatal ages to identify sex-biased gene regulation and cell-type proportion differences during development.

Single-cell mapper (scMappR): using scRNA-seq to infer cell-type specificities of differentially expressed genes

scMappR assigns cell-type specificity scores to bulk RNA-seq DEGs using scRNA-seq data and deconvolution methods, showing accurate assignment in kidney regeneration analysis.

Impaired Fetal Lung Development can be Rescued by Administration of Extracellular Vesicles Derived from Amniotic Fluid Stem Cells

The paper demonstrates that extracellular vesicles from amniotic fluid stem cells can rescue impaired fetal lung development in experimental models.