Simon A. Sharples

The paper discovers a new synaptic structure called the Honeycomb Synapse in the spinal cord, showing its vulnerability in ALS models.

This study shows HCN channels modulate mAHP amplitude and firing gain in fast alpha motoneurons, with no effect on slow motoneurons.

This study investigates how ion channels contribute to non-linear firing dynamics in postnatal mouse spinal motoneurons, showing that PICs and other channels like KCNQ, Kv1.2, and HCN play key roles in sustaining firing.

This study identifies intrinsic biophysical properties of gamma motoneurons in mice, revealing mechanisms underlying their low recruitment threshold and high firing rates.

This study identifies a spinal cholinergic pathway that enhances breathing by amplifying phrenic motor neuron output during hypercapnia.

This study shows that episodic rhythmicity in the developing mammalian spinal cord arises from a distributed network of interneurons, with afferent control and VLF projections playing key roles.

This study shows that M-type potassium currents influence motoneuron recruitment by modulating subtype-specific firing properties and recruitment gain in mice.

This study identifies CART and acetylcholine as modulators of motor neuron output at C bouton synapses, affecting movement vigour through distinct but parallel mechanisms.

The paper investigates how h- and Na+/K+ pump currents contribute to episodic and continuous rhythmic activities in spinal motor networks using computational models and experimental validation.

This study identifies how persistent and hyperpolarization-activated inward currents shape motoneuron subtype recruitment during postnatal development in mice.

This study investigates how dopamine receptors regulate spinal network output in neonatal mice, revealing concentration-dependent excitatory and inhibitory effects mediated by D1 and D2 receptors during low excitability states.