Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD
Melissa Parra-Torres, Kumara Dissanayake, James A. Gray, Alistair J. Langlands, Ridvan Kucuk, Marek Gierliński, Claire Troakes, Andrew King, Leeanne McGurk
This study identifies NSUN1-mediated m5C RNA methylation as a driver of TDP-43 cytoplasmic accumulation and neurotoxicity in ALS/FTD.
Life Science Alliance · Oct 17, 2025Peer-reviewedCell Biology